A semantic web rule language for geospatial domains

Retrieval of geographically-referenced information on the Internet is now a common activity. The web is increasingly being seen as a medium for the storage and exchange of geographic data sets in the form of maps. The geospatial-semantic web (GeoWeb) is being developed to address the need for access to current and accurate geo-information. The potential applications of the GeoWeb are numerous, ranging from specialised application domains for storing and analysing geo-information to more common applications by casual users for querying and visualising geo-data, e.g. finding locations of services, descriptions of routes, etc. Ontologies are at the heart of W3C's semantic web initiative to provide the necessary machine understanding to the sheer volumes of information contained on the internet. For the GeoWeb to succeed the development of ontologies for the geographic domain are crucial. Semantic web technologies to represent ontologies have been developed and standardised. OWL, the Web Ontology Language, is the most expressive of these enabling a rich form of reasoning, thanks to its formal description logic underpinnings. Building geo-ontologies involves a continuous process of update to the originally modelled data to reflect change over time as well as to allow for ontology expansion by integrating new data sets, possibly from different sources. One of the main challenges in this process is finding means of ensuring the integrity of the geo-ontology and maintaining its consistency upon further evolution. Representing and reasoning with geographic ontologies in OWL is limited. Firstly, OWL is not an integrity checking language due to it's non-unique name and open world assumptions. Secondly, it can not represent spatial datatypes, can not compute information using spatial operators and does not have any form of spatial index. Finally, OWL does not support complex property composition needed to represent qualitative spatial reasoning over spatial concepts. To address OWL's representational inefficiencies, new ontology languages have been proposed based on the intersection or union of OWL (in particular the DL family corresponding to OWL) with logic programs (rule languages). In this work, a new Semantic Web Spatial Rule Language (SWSRL) is proposed, based on the syntactic core of the Description Logic Programs paradigm (DLP), and the semantics of a Logic Program. The language is built to support the expression of geospatial ontological axioms and geospatial integrity and deduction rules. A hybrid framework to integrate both qualitative symbolic information in SWSRL with quantitative, geometric information using spatial datatypes in a spatial database is proposed. Two notable features of SWSRL are 1) the language is based on a prioritised de fault logic that allows the expression of default integrity rules and their exceptions and 2) the implementation of the language uses an interleaved mode of inference for on the fly computation (either qualitative or quantitative) deduction of spatial relations. SWSRL supports an OGC complaint spatial syntax, and a standardised definition of rule meta data. Both features aid the construction, description, identification and categorisation of designed and implemented rules within large rule sets. The language and the developed engine are evaluated using synthetic as well as real data sets in the context of developing geographic ontologies for geographic information retrieval on the Semantic Web. Empirical experiments are also presented to test the scalability and applicability of the developed framework

An evaluation of geo-ontology representation languages for supporting web retrieval of geographical information

The internet is the single largest information resource in the world. It is, however, not being used to is full potential. Currently most the information is written using syntactical machine readable languages such as HTML. These languages are limited in that they are only intended for human consumption. To fully unlock the potential of such a vast resource of information, we need to make the information not only machine readable but machine-understandable. In order to gain machine understanding we need semantic languages which are able to define meaning to the information being stored. Agents (human or machine) could then use this information in variety of different ways. A large amount of geographical information is currently being stored and delivered over the internet. Internet providers such as the Ordnance Survey are realizing the potential and are currently offering their data in GML format. Geographic digital libraries, such as the ADL, are being established. There is, however, the need to realize the potential of semantically enriching the geographic information to provide more automated and intelligent ways of managing and retrieving the data over the web

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease that usually affects elderly people. It has a poor prognosis and there are limited therapies. Since epigenetic alterations are associated with IPF, histone deacetylase (HDAC) inhibitors offer a novel therapeutic strategy to address the unmet medical need. This study investigated the potential of romidepsin, an FDA-approved HDAC inhibitor, as an anti-fibrotic treatment and evaluated biomarkers of target engagement that may have utility in future clinical trials. The anti-fibrotic effects of romidepsin were evaluated both in vitro and in vivo together with any harmful effect on alveolar type II cells (ATII). Bronchoalveolar lavage fluid (BALF) from IPF or control donors was analyzed for the presence of lysyl oxidase (LOX). In parallel with an increase in histone acetylation, romidepsin potently inhibited fibroblast proliferation, myofibroblast differentiation and LOX expression. ATII cell numbers and their lamellar bodies were unaffected. In vivo, romidepsin inhibited bleomycin-induced pulmonary fibrosis in association with suppression of LOX expression. LOX was significantly elevated in BALF of IPF patients compared to controls. These data show the anti-fibrotic effects of romidepsin, supporting its potential use as novel treatment for IPF with LOX as a companion biomarker for evaluation of early on-target effects

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes